<div class="bodyItems-wrapper"> By Sneha S K and Sahil Pandey Dec 31 (Reuters) - The U.S. Food and Drug Administration has declined to approve Corcept Therapeutics' drug for the ​treatment of a rare hormonal disorder, the company said on Wednesday. Shares ‌of the drugmaker were down 48% at $36.41. The company said the FDA could not arrive at a ‌favorable benefit-risk assessment for the hormone-blocking oral treatment, known as relacorilant, without Corcept providing additional evidence of effectiveness. The company was seeking approval for relacorilant as a treatment for patients with hypertension secondary to hypercortisolism. "FDA's request for additional data may require ⁠additional trials, significantly dimming Corcept's ‌outlook in Cushings," said Truist analyst Joon Lee. Hypercortisolism, also known as Cushing's syndrome, occurs when the body is exposed to ‍high cortisol activity. Corcept had submitted trial data that showed that relacorilant made improvements in a wide array of hypercortisolism's signs and symptoms. "We will meet with the FDA as soon ​as possible to discuss the best path forward," said Joseph Belanoff, Corcept's ‌CEO. Main symptoms of hypercortisolism include a fatty hump between the shoulders, a rounded face, and pink or purple stretch marks on the skin. People with Cushing's also experience diabetes, high blood pressure, muscle weakness and immune suppression. Relacorilant is a selective cortisol modulator designed to block the effects of cortisol, while avoiding certain ⁠off‑target hormonal effects. "Given the company had opportunities ​to address FDA's concerns during mid and late-stage ​reviews, it's unclear if any further dialogue can resolve the review issues without additional trials," Lee added. Corcept is also studying the ‍drug in a variety ⁠of serious disorders including ovarian and prostate cancer. Its other drug known as Korlym is approved to treat high blood sugar caused by ⁠hypercortisolism in adults with endogenous Cushing's syndrome. Other approved treatments for Cushing's syndrome include Isturisa by Recordati ‌and Xeris Biopharma's Recorlev. (Reporting by Sahil Pandey and Sneha S ‌K in Bengaluru; Editing by Shailesh Kuber) </div>

By Sneha S K and Sahil Pandey Dec 31 (Reuters) - The U. Food and Drug Administration has declined to approve Corcept Therapeutics' drug for the ​treatment of a rare hormonal disorder, the company said on Wednesday.

US FDA declines to approve Corcept's drug for rare hormonal disorder

March ICE NY cocoa (CCH26 ) on Thursday closed down -44 (-0.74%), and March ICE London cocoa #7 (CAH26 ) closed down -24 (-0.55%). Cocoa prices settled lower on Thursday, with NY cocoa falling to a 1-week low. Favorable weather in West Africa is expected to boost yields and supply,...

Cocoa Prices Settle Lower on Expectations of Adequate Supplies

Picking the right sort of cooking can fundamentally improve your feasting experience, giving sustenance as well as a wonderful


Pick Your Favored sort of cooking


Putting resources into home wellness gear can be an extraordinary method for remaining dynamic and solid without expecting to go to


Change Your Home into an Exercise center with These Famous Wellness Gadgets


Electric bikes, or e-bicycles, are turning out to be progressively famous in the U.S. for their benefit, eco-amicability, and capacity to make driving


The Electric Bicycle Americans Can Confide in 2024


Congrats on your new Android telephone! Securing another gadget is an intriguing encounter, and to guarantee a smooth and


10 Demonstrated Tips to Expand Your New Android Cell phone: A Thorough Aide


Retirement is a huge life change, and for the majority, it makes the way for another part loaded up with potential open doors


Flourishing in Retirement: Individual Accounts of Post-Vocation Satisfaction


The practice of this meditation often involves quietly reciting to oneself several phrases that evoke and visualize the beings who will receive loving-kindness.

What loving-kindness meditation is and how to practice it in the new year

Online work out regimes offer the adaptability and accommodation to work out whenever, anyplace, pursuing them an optimal decision for individuals


Vote in favor of the Web-based Work out schedule to Keep You Fit and Sound


Fish sweethearts, now is the right time to make your choice for your number one sea amuse. From delicious shrimp to rich and smooth lobster, the decisions are perpetual, however only one can rule. Fish dishes o


Most loved Fish Dish: What's Your Sea Pleasure?


Snacks are a fundamental piece of our regular routines, offering light meals of joy and energy between feasts. From appetizing


Vote In favor of Your Favored Kind Of Bites


Plotters misjudged the national mood and Benin's neighbours learnt from past errors, says analyst Paul Melly.

A coup too far: Why Benin's rebel soldiers failed where others in the region succeeded

While space is often referred to as a vacuum, it isn't completely empty.

Most normal matter in the universe isn't found in planets, stars or galaxies – an astronomer explains where it's distributed

Health Secretary Robert F. Kennedy Jr. says the flu shot isn't effective in protecting children. Here's what experts say.

RFK Jr. says fewer flu shots for kids may be 'better.' What experts say.

Tatiana Schlossberg, the journalist and author who was a granddaughter of John F. Kennedy, has died after revealing she had been diagnosed with cancer, her family announced Tuesday